The 10 Largest Lakes In Manitoba - WorldAtlas The Five Largest Lakes in Manitoba. 1. Lake Winnipeg. With a surface area of 24,387 km 2 and a mean depth of only 12 m, Lake Winnipeg is a large but relatively shallow lake. Located north of the city of Winnipeg, Lake Winnipeg is Manitoba's largest lake, and the sixth-largest freshwater lake in Canada. The Winnipeg River, Red River, and ...